Cutting-edge research and studies are changing how this disease (which strikes 29 million Americans) is classified, treated and prevented.

By Gina Roberts-Grey

1. Diabetes can be prevented with a pill. You’ve probably heard the name of this drug before. It’s called metformin and it’s a common first-line defense for type 2 diabetics. But what you haven’t likely heard is that by reducing glucose production by the liver and improving insulin resistance, metformin can help keep prediabetes from turning into full-blown diabetes. It’s safe and effective, yet one study revealed doctors only prescribe the drug to about 8% of those the American Diabetes Association’s guidelines recommend it for: prediabetics who are under age 60, severely obese or have a history of gestational diabetes. Experts surmise it’s being underprescribed because many doctors and patients seem to be unaware of the drug’s effectiveness, and a spate of studies have found that lifestyle changes were more effective than metformin at preventing diabetes. “An aversion to daily medicine could also make some people refuse the prescription,” explains Kevin Goist, MD, an assistant professor of internal medicine at The Ohio State University Wexner Medical Center.

However, the Centers for Disease Control and Prevention estimates that 15% to 30% of prediabetics will progress to type 2 within five years. “For those who are unable to change diets and incorporate more physical activity into their lives, metformin is a real opportunity to prevent or delay the onset of diabetes,” says endocrinologist Tannaz Moin, MD, the study’s lead author and an assistant professor at the David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System.

2. Even slim adults get diabetes. It’s been called type 1.5 diabetes and latent autoimmune diabetes in adults (LADA), but experts still haven’t settled on a definitive name for this disease that is often mistaken for type 2 diabetes. In fact, 20% of people diagnosed with type 2 could really have (what we’ll call for now) LADA, which typically occurs after age 30 and in patients who have low to normal BMIs. While symptoms of LADA can be the same as for other types of diabetes—extreme thirst, frequent urination, blurred vision and tingling in hands or feet—many patients don’t experience any of these. Instead they learn they have high blood sugar via blood work, usually during an annual physical.

While the terminology to use when talking about this disease is unclear, one thing isn’t: Unlike children with type 1, those diagnosed with LADA don’t immediately require insulin to regulate their blood sugar—avoiding medication for six months or longer. That means understanding LADA may open the door to future treatments. “Currently, the plan for all type 1 diabetics is the same: Use insulin to regulate blood sugar,” says Matt Petersen, managing director of medical information for the American Diabetes Association. “But if we unlock the reason those diagnosed with LADA have a ‘honeymoon’ period before needing medication, we may be able to prevent the need for others to be insulin-dependent.”

3. There’s a breast cancer link. The demands of managing diabetes could be one of the reasons women with the disease are up to 20% less likely to get mammograms, increasing their risk of having breast cancer diagnosed at a more deadly stage. Insulin resistance and high blood sugar levels may also promote more rapid growth of tumors. Source: Women’s College Research Institute in Toronto, Canada

4. Diabetes may harm your memory. A small study out of Harvard Medical School showed that people with type 2 diabetes aren’t able to regulate blood flow to their brain as well as nondiabetics do. That diminished blood flow may negatively impact brain health and cognitive abilities and could be one reason having diabetes was associated with an increased risk of Alzheimer’s by researchers in Taiwan. New research has found that diabetics also have less gray matter in parts of the brain responsible for memory retrieval, an early risk factor for dementia.

Type 1 diabetes could be just as bad for your brain, aging it faster than normal, which impairs the processing of information and cognitive abilities, according to University of Pittsburgh researchers. “One possibility is that diabetes potentially causes changes to blood vessels and other parts of the vascular system throughout the body that may affect brain health, but more research is needed,” says Heather Snyder, PhD, director of medical and scientific operations of the Alzheimer’s Association.

There is some good news: A large German study found that managing blood sugar with the anti-diabetic drug pioglitazone reduces the risk of dementia by 47% in type 2 diabetics who aren’t taking insulin. The medicine’s anti-inflammatory abilities coupled with decreasing insulin resistance are believed to offer protective benefits to parts of the brain impacted by dementia.

5. A “healthy” diet isn’t necessarily enough. Skipping sweets and sticking to good-for-you foods doesn’t guarantee you won’t develop diabetes. Unfortunately, the majority of American diets are stuck in a rut consisting of the same few items. Instead of filling their plates with a variety of fruits, nuts and veggies, most Americans typically pair meat and dairy with a rice-, corn- or wheat-based partner. This unbalanced eating pattern has reduced the assortment of gut bacteria, which is believed to help regulate blood sugar levels and inflammation as well as hormones that trigger a sense of fullness. One recipe for balanced belly flora is simple: Add several different fiber-rich foods to your diet. Go beyond brown rice, oatmeal or whole-grain toast and try incorporating fiber-rich seasonal fruits and vegetables and a variety of nuts and legumes to keep your gut bacteria balanced. And make it a goal to get more than 26 grams of fiber a day. Consuming at least that much tames spiking blood sugar levels, lowering the risk of diabetes by 18%, according to the InterAct Consortium, a European union of diabetes researchers.

Dairy or seafood can also be protective. Separate studies have determined that vitamin D, which is found in milk, yogurt, eggs, salmon and tuna, stimulates production of gut bacteria shown in animal studies to inhibit the pancreatic inflammation thought to lead to type 1 diabetes.

6. Lowering your cholesterol can raise your blood sugar. The heart-healthy practice of decreasing LDL cholesterol and triglycerides with a prescription statin may significantly increase your risk of developing diabetes. It may also indirectly raise your chances of experiencing diabetes complications like kidney disease, elevated blood sugar–induced coma and eye disease. Experts believe one possibility is that the drug reduces muscle strength and conditioning. “When you lower muscle bulk, your body uses fewer calories during the day, making it easy to gain weight if you don’t watch what you eat,” says Ishak Mansi, MD, physician and professor at UT Southwestern Medical Center and the study’s lead author. “Another reason may be that people taking statins to keep cholesterol in check may permit themselves to eat whatever they want, which increases weight and the risk of diabetes.”

Mansi isn’t suggesting that anyone stop taking statins. But he does advocate making an effort to lower your risk of cardiovascular disease by quitting smoking, exercising regularly and maintaining a healthy body weight. You might also ask your doctor about statin alternatives like proprotein inhibitors, a new class of injectable medicines that also treat high cholesterol, or embracing a Mediterranean lifestyle, which research from the University of Texas found can lower triglycerides and lower LDL cholesterol. “That means eating olive oil, vegetables, fruits, legumes, whole-grain foods, nuts, cheese and yogurt daily; limiting red meat meals to once a week or less; having fish twice a week; getting daily physical activity and adequate rest; and enjoying moderate alcohol consumption,” says Labros Sidossis, PhD, professor at University of Texas Medical Branch at Galveston and lead author of the study. “No single component can have a very significant effect alone.You need the whole Mediterranean package.”

7. Diabetes is a couple’s disease. A recent Canadian study found that having a wife with diabetes increases a man’s chance of developing type 2 diabetes by 26%, possibly because partners often share similar dietary and exercise habits. Source: McGill University Health Centre

8. Diabetes can be a side effect of menopause. Along with hot flashes and night sweats, several studies have found decreased estrogen and progesterone during perimenopause and menopause are linked to your insulin resistance and raise the risk of diabetes. “Insulin resistance makes us crave sugar, and satisfying that craving promotes belly fat. The excess weight leads to greater insulin resistance and the vicious cycle continues,” says ob-gyn Diana Bitner, MD, NCMP, of Spectrum Health Medical Group, Women’s Health Network in Grand Rapids, MI. Extra fat lingering around your midsection may mean more frequent hot flashes, causing stress and even depression. “When that happens, many women look for comfort in the form of a simple carbohydrate like candy, sweets and sugary drinks, keeping themselves stuck on that merry-go-round.” Research has shown lifestyle changes like increasing activity levels and healthy diets can counter hormone-induced insulin resistance. To keep your blood sugar in check, Bitner also suggests consulting a certified menopause practitioner (go to to discuss all effective ways to improve insulin resistance.

9. Your bones should beware. Diabetics with uncontrolled blood sugar have an increased risk of fractures and decreased bone strength, according to new research out of the University of Delaware. The good news is that exercise can help build stronger bones, so long as your diabetes is well controlled.